Increase of the hypoglycemic action of chlorpropamide caused by an isonicotinoyl-hydrazine

Abstract

A study has been made on dogs, under chloralose anesthesia, of the effect of i-(2 -’(benzylcarbamyl) - ethyl-2-isonicoti- nol hydrayde (BEIH), alone or in conjunction with chloropropamide, on glycaemia (o, 30, 60 and 90 min.). With BEIH (10 mg/kg) through the jugular vein a slight hyperglycaemia was produced and, through the saphenous, a slight hypoglycaemia. The chloropropa­ mide (3 mg/kg) produced hypoglycaemia through both. The association of the two de per kg) produced an increase in the (10 mg BEIH + 3 mg Chloropropami-hypoglycaemia effect of the chloropropa­mide, whether in the saphenous or in the jugular veih.