Action of persantin on hydrocyanic poisoning

Abstract

A pyrymido-pyrimidinic substance (Persantín) seems to posses a meclianism of metabolic action related to the cellular respiratory processes. The authors study the interferences between this drug and a typical substan­ce of antioxygenic action, the potassiumcyanide.

Two groups of dogs anaesthetized with chloralose-uretliane have been tested:

a) tested group (12 animals) received potassium-cyanide at 1 per 1.000 in the quantity of 1 mi/10 kg/min.

b) problem group (24 animals) which previously received ten minutes before begining the infusión of cyanide, a dosis of Persantin of 0,5 to 10 mg/kg intravenously.

A continuous electrocardiographic re­ cord of all the animáis is effected, besides controlling the lethal dosis of cyanide in all of them. The electrocardiographic modifications were similar in both groups. A greater quantity of lethal dosis was definitely needed in those animals who had previously received Persantin (p <Z 0,001).