Antagonism between serotonin and Th-1165a in the isolated uterus of the rat

A. Brugger
M. Sopena
J.A. Salvá
56

Abstract




Antagonism between serotonin and Th-1165a in the isolated rat uterus


The activíty of Th-1165a (a beta stimuling agent) is studied at molecular le­vel as serotonin antagonist. The Th-1165a, is a non competitive antagonist of seroto­nin, with a very much higher activity in front of serotonin, that in front of oxytocin. Its pD' is 9.7 +- 0.15.




Keywords:
Serotonin Antagonists, Amino Alcohols/pharmacology, Animals, Female, In Vitro Techniques, Muscle Contraction/drug effects, Rats, Sympathomimetics/pharmacology, Uterus/drug effects

Authors

A. Brugger
M. Sopena
J.A. Salvá


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