Mechanism of action of 2-(2,6-dichlorophenylamine)2-imidazoline hydrochloride. Experimental studies in normal animals

Abstract

The mechanism of action of 2-(2,6 dichlorophenylamine) 2 imidazoline Hydrochloride (ST-155) in anesthetized dogs on various experimental conditions which modifie sympathetic tonus, is studied. It is concluded that when the sympathetic tonus is low ST-155 acts as a hypertensive and vice versa. In this way the dualist action of the product previously observed in vitro has been confirmed.
ST-155 depress cardiac function and this contributes to the hypotensive effect. This cardiac depression is more marked in reserpinized dogs.