Antagonism between oxytocin and Th 1165a in isolated rat uterus

Abstract
The antagonism type, at molecular level, from Th 1165a, in front of Oxytocin induced contractions of rat uterus is studied. The activity is comparated with the Orciprenaline one. The antagonism between Th 1165a, and Oxytocine is of non-competitive-type. Th 1165a is from 7.06 to 7.42 times stronger that Orciprenaline.
Keywords:
Animals, Ethylamines/antagonists and inhibitors, Female, Muscle Contraction/drug effects, Oxytocin/antagonists and inhibitors, Rats, Resorcinols/antagonists and inhibitors, Sympathomimetics/antagonists and inhibitors, Uterus/drug effects
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