Antagonism between Th 1165 and vasopressin on the isolated rat uterus

Abstract
The antagonism between vasopressin and Th 1165a, is studied at molecular level. Th 1165a is an non competitive antagonist of vasopressin (arginil). Its pIT, is 9.1897 + 0.508297. As antagonist of the vasopressin, Th 1165a is stronger than orciprenalin. In front of oxitocin the antagonistic action of Th 1165a is fewer than in front of vasopressin.
Keywords:
Animals, Female, Rats, Sympathomimetics/pharmacology, Uterus/drug effects, Vasopressins/antagonists and inhibitors
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