In vitro study of inhibition of adenosine-deaminase by dipyridamole

Abstract

It has been studied in vitro the antagonismos of dipiridamol and adenosin-desaminase. It’s concluded that dipiridamol is a competitive inhibitor of adenosin-desaminase. The valué of Ki obtained relating the reciproca! valué of inicial velocity of the enzimatic reaction with the concentration of dipiridamol is of 0.16 mM. With the concen­ traron of enzime employed we obtain an inhibition of 46 and 56 % of its activity in presence of concentrations of dipiridamol of 0.3 and 0.6 mM.