Inhibition of O2 uptake of rat jejunum by x-irradiation in vitro". Protection by cysteamine"

Abstract

A study has been made of the effect of X irradiation in vitro of strips of rat jejunum on the O”ž uptake of the tissue.

The X irradiation (50 KV, 1 mm Al, i,ouo rp.m.) produces a decrease in the O3 uptake which first appears after 2 or 3 hours of recording and becomes more apparent as time goes on. The effect can already be no­ ticed with 5,000 r and is greater at 10,000 and 20,000 r. We have also observed inhibi­ tion of the O. uptake when there is glucose (2.77 mM) in the medium.

The presence of cysteamine 0.02 M during the irradiation absolutely protects the prepa­rations from these inhibitory effects on the uptake.