Experimental study on the mechanism of action of 2-(2,6 dichlorophenylamine)-2-imidazoline hydrochloride (ST-155)
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26)
Published:
1969-12-01
Keywords:
Adrenergic alpha-Agonists/pharmacology, Animals, Clonidine/pharmacology, Drug Interactions, Imidazoles/pharmacology, Male, Muscle, Norepinephrine/pharmacology, Rats, Smooth/drug effects, Vas Deferens/drug effects
How to Cite
Experimental study on the mechanism of action of 2-(2,6 dichlorophenylamine)-2-imidazoline hydrochloride (ST-155). (1969). Revista Española De Fisiología, 25(4), 233-237. https://revistas.unav.edu/index.php/ref/article/view/49143
48
Abstract
Experimental Study on Action’s Mechanism of 2-(2,6 Dichlorphenylamine) 2 Imidazoline Hydrochloride
Interaction between nor-apinephrine and ST-155 is studied at molecular level on isolated deferens vas of rat; ST-155 acts as partial agonist like on the alfa receptors. His intrinsec activity is 0.37 + 0.09 and pD2 4.52 ± 0.45 equivalent to a KA médium 29.88 X 10-6 M.
Keywords:
Adrenergic alpha-Agonists/pharmacology, Animals, Clonidine/pharmacology, Drug Interactions, Imidazoles/pharmacology, Male, Muscle, Norepinephrine/pharmacology, Rats, Smooth/drug effects, Vas Deferens/drug effects
Authors
A. Brugger
J.A. Salvá
M. Sopena
R. Oliver
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