Contribution to the pharmacological study of fluorescein

Abstract

In the course of our experiments we have been able to observe the following qualities of the fluoresceine:

The fluoresceine possesses a protective action ≪in vivo≪ against the deadly anaphylactical shock in the cobaye, and it diminishes ≪in vitro≪ the intensity of the reply to the anaphylactic agent introduction.

The fluorescein causes in dogs and cats a constant and clear tension fall, all the times that it will be injected. This inflection on the arterial pressure curve, is modified in a negative sense and annulated by the atropine innuence, reappearing slowly after wards.

The tension fall produced by the fluoresceine after having injected acetylcholine, offers several characteristics in form and intensity, increasing the fall magnitude. This effect lasts half an hour after the acetylcholine injection. On the other hand the acetylcholine reply is some more intense in the fluoresceinated animal.

The fluoresceine does stimulate the, smooth fiber of thin bowels of rabbit, rect of cobaye and in less proportion, those of the uterus of this animal.

The fluoresceine reenforces the action of acetylcholine upon the above mentioned organs, histamine and barium chloride. In the virginal uterus increases slightly the pituitaric action and in the gravidics it offers a clear synergics with the acetylcholine.