Fibrinolysis regulation by the spleen

Abstract

In this work, the possible effect of the spleen on coagulation was studied. White Wistar rats were used as experimental animals, divided in three lots: normal, control and de-spleened animals.

The classic chronometrical tests of coagulation were done, and some special tech­ niques, as the coagulography and the thromboelastography. According to the results, a hypocoagulability was observed. By other hand, the fibrinogen increased. By this, the presence of the circulating anticoagulants was deduced. By the neutralization test of protamine-sulphate, the heparin is not present in abnormally amounts. By immuno­ logy, products of the fibrinogen degradation were detected in the blood, and they have a anticoagulant role.