Adrenotrophic action of ACTH in thyroidectomized rats

Abstract

Normal rats were thyroidectomized at an early age and kept on low iodine diet with two group controls (age and weight). After the experimental period the adrenal weight was recorded and significant differences were found between age control and thyroidectomized rats, and between the late group and weight control rats when injected with ACTH. This could be interpreted as a permissive effect of the thyroid hormones on the action of ACTH on the adrenal gland.