Effects of neomicine on the transport of sugars by rat and hamster small intestine

Abstract

Effects of Neomicine on the Transport of Sugars by fíat and Hámster Small Intestine. Rev. esp. Fisiol., 30, 183-190. 1974.

The in vivo absorption of 2.77 mM galactose or 50 mM arabinose by the small intestine of rat strongly increases when neomicine (6 or 18 mM) is present in the luminal solution. Neomicine, at 6 mM, also increases the absorption of 2.77 mM glucose. These effects dissapear by washing the intestine with saline. However, 18 mM neomicine obviously inhibits the glucose absorption, persisting the inhibition after removing the antibiotic by washing.

The presence of neomicine in the intestinal lumen produces apparent morphological alterations in rat, changes which were not observed in hámster.

The active transport of glucose or galactose by everted sacs of rat intestine or the accumulation of these sugars by intestinal rings of hámster were not significantly modified by neomicine in the médium.

The increases of sugar absorption in the rat in vivo are attributed to a reversible interaction of neomicine with luminal membrane constituents, different from the transport systems, leading to a greater permeability.