Effect of a beta-adrenergic blocking agent on erythropoietin production in the mouse

E.E. Guidi; J.L. Scaro; M.A. Carrera

E.E. Guidi

J.L. Scaro

M.A. Carrera

PDF (Spanish) (

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Published: 1976-06-01

Keywords:

Animals, Carbon Monoxide Poisoning/drug therapy/metabolism, Erythropoiesis/drug effects, Erythropoietin/biosynthesis, Inbred C3H, Iron Radioisotopes, Mice, Oxygen Consumption, Partial Pressure, Propranolol/metabolism/pharmacology/therapeutic use

How to Cite

Effect of a beta-adrenergic blocking agent on erythropoietin production in the mouse. (1976). Revista Española De Fisiología, 32(2), 149-152. https://revistas.unav.edu/index.php/ref/article/view/49503

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Abstract

The effects of the beta-adrenergic blocking agent (propranolol) on erythropoietin production in carbon monoxide intoxicated mice were studied. The raise in plasma erythropoietin after a 4 hour intoxication with carbon monoxide was 47% less in the propranolol treated group. A decrease of 65% in the endogenous erythropoietic response after 75 minutes of carbon monoxide intoxication was found in policithemic treated mice, as against the untreated ones. The tissue oxygen tension was reduced in the propranolol treated group. No changes was found in the hemoglobin oxygen affinity.

Keywords:

Animals, Carbon Monoxide Poisoning/drug therapy/metabolism, Erythropoiesis/drug effects, Erythropoietin/biosynthesis, Inbred C3H, Iron Radioisotopes, Mice, Oxygen Consumption, Partial Pressure, Propranolol/metabolism/pharmacology/therapeutic use