Influence of tetraethylammonium ion on the effects of anoxia, hypercapnia and asphyxia on the pulmonary circulation.

Abstract

The injection of tetraetylamonium —TEA— prevents almost completely the pressor action in pulmonary circulation produced by respiration in hipercapnia. This appears to show that pressure elevation is fundamentally of a reflex nature. In the same conditions an evident pressor response throngh respiration of oxygen al 10 per cent is always observed, which shows that anoxia is capable of effecting a Chemical action increasing the peripheric resistance in pulmonary circulation. Anoxia as well as asphyxia can also have an important reflex influence, as can be deducted from the fact that the acute effect appearing in some cases, never occurs in the same wav after injecting TEA.