Study of the movements of the isolated guinea pig gallbladder. Its behaviour in response to the action of water-soluble vitamins.

Abstract

In order to obtain spontaneous movements of the isolated guinea pig bile bladder a period of repose of this organ called adaptation time is necessary in most cases. This is on an average of 35 minutes. The spontaneous movements observed have been of two kinds: slow contraction and small rapid contractions. Refrigerated bladders show in some cases stronger spontaneous contractions than fresh ones.

Vitamines B1-B2-C and P.P act on the isolated guinea pig bile bladder producing inhibitions of contraction and relaxation. All act with about the same intensity. The vitamin action does not show itself on vesicular fibre tone, a state of more energetic contraction being necessary for relaxation. Vitamins B1-C and P.P act in all probability on the nerve ends, as they are sympathicotropic. Vitamin B2 acts probably on the muscle fibre itself.