Distribution in tissues and effects by acute hypoxia on angiotensin I converting enzyme activity in guinea pig and chicken

Abstract
Angiotensin I converting enzyme activity was measured in homogenates of guinea pig and chicken organs (lung, kidney, heart, ileum, diaphragm and liver), using a spectrophotometric assay for hydrolysis of hippuryl-L-histidyl-L-leucine.High specific activities were found in lung, kidney and diaphragm, but the highest corresponded to guinea pig lung and chicken kidney.Acute hypoxia decreased angiotensin I converting enzyme activity in guinea pig lung and chicken diaphragm, but the changes in kidney were considered non-significant in both the guinea pig and chicken.
Keywords:
Animals, Chickens, Diaphragm/enzymology, Dogs, Guinea Pigs, Hypoxia/enzymology, Kidney/enzymology, Lung/enzymology, Mice, Peptidyl-Dipeptidase A/analysis, Rabbits, Species Specificity, Angiotensin I Converting enzyme, Tissue distribution Guinea pig
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