Role of the presynaptic receptors in the control of dopamine synthesis in the striate complex and nucleus accumbens

Abstract

The role of presynaptic receptors on dopamine synthesis, at both nigrostriatal and mesolimbic systems, has been studied after dopamine uptake drastically increases the dopamine and DOPAC levels at n.accumbens but not at striatum.The present data suggest that presynaptic receptors are a decisive factor regulating dopamine synthesis at nigrostriatal system.However, the end-product inhibition could be the most important autoregulatory mechanism at the mesolimbic system.