Effect of sodium butyrate treatment of HeLa cells on the transcriptional activity of their isolated nuclei
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30)
Published:
1981-06-01
Keywords:
Butyrates/pharmacology, Butyric Acid, Cell Nucleus/drug effects/metabolism, Electrophoresis, Genetic/drug effects, HeLa Cells/metabolism, Histones/metabolism, Humans, Peptide Chain Initiation, Polyacrylamide Gel, RNA/biosynthesis, Transcription, Translational/drug effects
How to Cite
Effect of sodium butyrate treatment of HeLa cells on the transcriptional activity of their isolated nuclei. (1981). Revista Española De Fisiología, 37(2), 147-152. https://revistas.unav.edu/index.php/ref/article/view/46673
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Abstract
Sodium n-butyrate has been used as a tool to study the presumptive effects of the in vivo hyperacetylation of histones from HeLa cells on the transcriptional activity of their isolated nuclei.No gross differences were found in either initiation or RNA synthetic capacity among the nuclei from control or butyrate treated cells.The electrophoretic pattern of the RNA synthesized in nuclear suspensions was markedly affected by prior exposure of the cells to the fatty acid.
Keywords:
Butyrates/pharmacology, Butyric Acid, Cell Nucleus/drug effects/metabolism, Electrophoresis, Genetic/drug effects, HeLa Cells/metabolism, Histones/metabolism, Humans, Peptide Chain Initiation, Polyacrylamide Gel, RNA/biosynthesis, Transcription, Translational/drug effects
Authors
R. Castro
A. Pestaña
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