Cardiovascular action of a new beta receptor blocking agent: KO 592

A.J. Brugger

A.J. Brugger

PDF (Spanish) (

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Published: 1967-12-01

Keywords:

Adrenergic beta-Antagonists/pharmacology, Animals, Blood Pressure/drug effects, Dogs, Electrocardiography, Heart Rate/drug effects, Sympatholytics/pharmacology

How to Cite

Cardiovascular action of a new beta receptor blocking agent: KO 592. (1967). Revista Española De Fisiología, 23(4), 215-220. https://revistas.unav.edu/index.php/ref/article/view/49083

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Abstract

Kö 592 stops the action of the beta receptors, by acting on the same sites as propranolol.

There exists a strong relationship between the dose of Kö 592 administered and the reduction in cardiac frequency obtained.

The effective dose of Kö 592 required to decrease cardiac frequency by 50 % is 0.0788 mg/kg.

Keywords:

Adrenergic beta-Antagonists/pharmacology, Animals, Blood Pressure/drug effects, Dogs, Electrocardiography, Heart Rate/drug effects, Sympatholytics/pharmacology