Action of the contact factor on the aggregation of the platelets

Abstract

The authors study the action of the Contact Factor on the platelet aggregation. For this purpose, they use an elution of Contact Factor obtained as per Nossel’s technique. Such elution it has been proved, possesses a biolocal activity of Contact Factor.

The action of the said elution is valued on the aggregation of the platelets in a series of normal people, and the fact that it brings about a significant reduction of the thrombocyte aggregation is duly checked.

For a valuation of the platelet aggregation, the continuous photocolorimetric measurement has been used, the platelets having been activated with collagen.

Finally, a series of considerations are carried out concerning the likeable connection of this fact with the tendency to thromboembolic accidents previously described in patients suffering from Hegeman disease.