Effects of dipyridamole on glucose absorption in the rat intestine in vitro

Abstract

The effect of Dipyridamol on glucose absorption was studied in everted sacs of rat small intestine incubated in Krebs-Ringer-bicarbonate solution. The drug (0.5 mM) did not show any effect when it was added only to the mucosal fluid. However, when Dipyridamol was added to the serosal fluid, it produced an small but significant inhibition of glucose utilization by the tissue, which resulted in an increased net transfer or sugar to the serosal side and a rise of the serosal/mucosal concentration ratios at the end of incubation. The mucosal uptake of glucose (entry of sugar into the cells from the mucosal fluid) was not changed by the drug.