Effect of cardioactive steroids on active intestinal sugar transport in hamster

Abstract

The effect of ouabain, convallatoxin, cymarin, digitoxin, thevetin, and lanatoside C on the accumulation of D-galactose by rings of hámster small intestine has been studied. The results shown that ouabain, convallatoxin and cymarin, when added to the médium of incubation at concentrations 10-4 to 10“’ M inhibits the active accumulation of galactose. The digitoxin, thevetin, and lanatoside C did not effect the active transport of this sugar in the same conditions.

The effect of ouabain on the active transport of galactose by everted sacs of hámster small intestine is greater when the glycoside is present in the serosal side that when is in the mucosal side.

The results are explained as due to differences in the polarity of cardiac steroids and to specificity of animal experimentation.