Influence of linoleic and linolenic acids, and choline on fatty acid metabolism rat kidney

Abstract

Changes induced by dietary ethyl linoleate plus linolenate and choline in the fatty acid composition of kidney phosphatides were investigated in essential fatty acid-deficient rats. The fatty acid composition of phosphatides was estimated by gas-liquid chromatography. From the compositions found it was deduced that linoleate and linolenate inhibit eicosatrienoic synthesis from oleate; both essential fatty acids are converted into long chain polienoic fatty acids; linolenate and its derivatives inhibit the incorporation of linoleate and its derivatives into phosphatides. Choline fed-rats show a greater inhibition of eicosatrienoic and arachidonate incorporation into phosphatides, while levels of linoleate and docosahexaenoate increase.