Variations produced by insulin coma in the effect of codeine and morphine on arterial pressure

Abstract

The effects of minimum hypotensive doses of codein and morphine are compared in the dog anesthetized by chloralose and in the dog comatose by insulin administraron. In dogs anaestlietized by chlora­ lose the hypotension produced by injection of codein through the carotid artery was preceded by a slight hipertensive phase. This was mofe marked in the dog comatose by insulin, in which hypotension did not take place.

Morphine did not produce the initial hypertensions as did codein injected through the carotid artery, neither in dogs anacsthetized by chloralose, nor in dogs comatose by insulin. There was no qualitative difference between the effects of codein or morphine on anaesthefized and on comatose dogs, when these drugs were injected through the saphene vein.