Effect of phosphorylcholine and dextran sulfate on the goitrogenic action of propylthiouracil
Article Sidebar
25)
Published:
1971-12-01
Keywords:
Animals, Choline/pharmacology/therapeutic use, Dextrans/pharmacology/therapeutic use, Drug Evaluation, Goiter/chemically induced/drug therapy, Male, Organ Size, Propylthiouracil, Rats, Thiouracil/pharmacology/therapeutic use, Thyroid Gland/drug effects
How to Cite
Effect of phosphorylcholine and dextran sulfate on the goitrogenic action of propylthiouracil. (1971). Revista Española De Fisiología, 27(4), 325-330. https://revistas.unav.edu/index.php/ref/article/view/49227
48
Abstract
In rats male Wistar, 200 to 250 g weigth, have been demonstrated that the phos phorylcholine (PC) and dextran sulfate (DS) inhibit the goitrogenic action of propyl thiouracil (PTU), with significatively disminution of thyroid weight, increase of the thyroid uptake I131, the thyroid I13T, the serum PBI13’ and FBI137 and remarkable rise of thyroid hormonal synthesis.
It is probably that the modifications on the lipide metabolism that both substances (PC and DS) produce, have not relations with their effect on the PTU goiter.
Keywords:
Animals, Choline/pharmacology/therapeutic use, Dextrans/pharmacology/therapeutic use, Drug Evaluation, Goiter/chemically induced/drug therapy, Male, Organ Size, Propylthiouracil, Rats, Thiouracil/pharmacology/therapeutic use, Thyroid Gland/drug effects
Authors
M. Muñóz-Rodríguez
E.Torrano-San Francisco
Metrics
|
|
Downloads
Download data is not yet available.
Issue
Section
Articles