Action of hexachlorocyclohexane and D. D. T. on phosphatase processes

Abstract

The qualitative study of the action of D.D.T. and 666 on alkaline phosphatase of intestine is accomplished, utilizing them in the form of a fine oily emulsion by means of borax as emulsionating agent. The evolution of the corresponding hydrolytieal processes is followed utilizing the sodium meta-tolil-azo-phenyl phosphate as substrate, which is rapidly split at the ordinary room temperature. This is not the case with sodium pheuolphthalein phosphate which only permits (he appreciation of the final phase of this above mentioned processes.

Both, 666 and D.D.T., show an inhibitory action on alkaline phosphatase of intestine, greater with 666 than with D.D.T., at least in the experimental conditions which have been described in this paper.