Intestinal glucose absorption in adrenalectomised rats and the immediate effect of deoxycorticosterone in adrenalectomised and normal rats

S. Vidal-Sivilla
41

Abstract

The intestinal absorption of glucose in adrenalectomized and normal rats has been studied with the aid of Sols and Ponz’s method of successive absorptions.


In adrenalectomized rats a decrease of absorption of about 50 per cent, with an ample range of variability has been observed. Moreover, they showed a- further progressive decrease of the absorption capacity in successive experiments, thus strikingly contrasting with the typical constancy in the normal animals. From this and from the postoperatory course, it is deduced that the animals were in a shocklike State, which may in itself account for the absorption decrease. The lack of cortical hormones and the subsequent disturbances of the salt metabolism would act only as factors predisposing to surgical shock. An analogous interpretation is suggested to explain the results of other authors, including of those who have utilized Cori’s method.


The endovenous administration of desoxycorticosterone (hidrosoluble Percorten) did not prevent the progressive decrease of absorption capacity in adrenalectomized rats nor modify the constancy of the normal ones.


It is concluded that the desoxycorticosterone has no immediate and direct action on the intestinal absorption of glucose in either normal or adrenalectomized rats.


Authors

S. Vidal-Sivilla


Metrics

Search GoogleScholar



Downloads

Download data is not yet available.

Section

Articles

Most read articles by the same author(s)